Dr. David H. Sachs is a Professor of Surgery at Columbia University and the Paul S. Russell Professor Emeritus at Harvard Medical School and Massachusetts General Hospital (MGH). He received his A.B. in Chemistry, Summa cum Laude, from Harvard College in 1963, a D.E.S. from the University of Paris in 1964, and his M.D., Magna cum Laude, from Harvard Medical School in 1968. His postdoctoral training included surgical residency at the MGH, followed by fellowships in biochemistry and immunology at the NIH, where he became Chief of the Immunology Branch of the National Cancer Institute and directed a program in transplantation research. In 1991, he returned to the MGH as Director of the Transplantation Biology Research Center and Professor of Surgery at Harvard Medical School. In July 2015, he became Professor of Surgery at Columbia University Medical Center and an Investigator in the Columbia Center for Translational Immunology (CCTI). Throughout his career, Dr. Sachs has worked at the interface between basic science and clinical applications in the field of transplantation. He has worked extensively on transplantation tolerance and xenotransplantation in small and large animal models and has published over 700 research articles. His research achievements include: 1) discovery of Ia (Class II) antigens in 1973; 2) development of monoclonal antibodies to MHC antigens; 3) development of a unique large animal model for transplantation using miniature swine; 4) use of mixed marrow reconstitution as a means of inducing specific transplantation tolerance; and 5) studies of specific transplantation tolerance to allografts and xenografts in murine, swine and primate models. In 2008, his team reported the first successful clinical trial for the induction of transplantation tolerance across HLA barriers in patients receiving renal transplants. He was the founding Editor of Xenotransplantation and one of the three North American Editors of Transplantation. He is a member of the National Academy of Sciences and has received numerous honors and awards, including the Thomas E. Starzl Prize in Surgery and Immunology and the Medawar Prize, awarded by the Transplantation Society. Dr. Sachs is married and has 4 children and 11 grandchildren. He enjoys sailing, fishing, skiing, woodworking and gardening. He speaks English, French, Swedish and German.